Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.

@article{Williamson1966MechanismFT,
  title={Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.},
  author={John R. Williamson and R. Kreisberg and P W Felts},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1966},
  volume={56 1},
  pages={247-54}
}
Communicated by B. Chance, May 6, 1966 The pathway of gluconeogenesis is distinguished from that of glycolysis by several enzyme reactions which overcome the energy barriers preventing a direct reversal of glycolysis.I These reactions are* catalyzed by pyruvic carboxylase, PEP-carboxykinase, fructose-1,6-diphosphatase, and glucose-6-phosphatase. Considerable emphasis has been placed on the possibility that control of the rate of gluconeogenesis may be exerted at one or more of these sites since… CONTINUE READING

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