Mechanism for the gastrokinetic action of domperidone. In vitro studies in guinea pigs.

To test the hypothesis that domperidone stimulates gastric muscle contraction by antagonizing the inhibitory effects of dopamine on postsynaptic cholinergic neurons in the myenteric plexus, the effects of dopamine on circular muscle from the body of the guinea pig stomach were examined. Dopamine inhibited circular muscle contraction evoked by electric field… CONTINUE READING