Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme.


The CCA-adding enzyme synthesizes the CCA sequence at the 3' end of tRNA without a nucleic acid template. The crystal structures of class II Thermotoga maritima CCA-adding enzyme and its complexes with CTP or ATP were determined. The structure-based replacement of both the catalytic heads and nucleobase-interacting neck domains of the phylogenetically… (More)
DOI: 10.1038/emboj.2009.260


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