Mechanism for the Increased Permeability in Endothelial Monolayers Induced by Elastase

  title={Mechanism for the Increased Permeability in Endothelial Monolayers Induced by Elastase},
  author={Norihiko Suzuki and Yuji Ishii and Soichiro Kitamura},
  journal={Mediators of Inflammation},
  pages={11 - 16}
The aim of this study was to investigate the mechanism for the increase in endothelial permeability induced by human neutrophil elastase (HNE). Pretreatment of bovine pulmonary artery endothelial cells (BPAEC) with HNE(0-30 mug/ml) for 1 h produced a concentration dependent increase in (125)I-albumin clearance. The effect was reversible and was not due to cytolysis. Pretreatment of BPAEC with sodium tungstate, which depletes xanthine oxidase, or with oxypurinol, did not prevent HNE induced… CONTINUE READING


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