Mechanism for the Cholesterol-Lowering Action of Egg White Protein in Rats

  title={Mechanism for the Cholesterol-Lowering Action of Egg White Protein in Rats},
  author={Ryosuke Matsuoka and Mamoru Kimura and Ayano Muto and Yasunobu Masuda and Masao Sato and Katsumi Imaizumi},
  journal={Bioscience, Biotechnology, and Biochemistry},
  pages={1506 - 1512}
Eggs are a popular source of dietary cholesterol, but their consumption does not necessarily result in an increased serum cholesterol concentration. We investigated the cholesterol-lowering activity of egg white protein (EWP) and its potential mechanism in rats. The consumption of EWP resulted in a decreased concentration of cholesterol in the serum, liver and intestinal mucosa. The excretion of fecal neutral sterols and bile acids was greater by rats fed with EWP than by those fed with casein… 

Egg phospholipids exert an inhibitory effect on intestinal cholesterol absorption in mice

In vivo evidence is provided that acute administration of PLs in eggs prevent cholesterol absorption in the intestine, suggesting a mechanism for a minimal effect of egg consumption on circulating cholesterol levels.

Dietary egg white protein inhibits lymphatic lipid transport in thoracic lymph duct-cannulated rats.

Dietary egg white protein (EWP) decreased cholesterol intestinal absorption by exerting combined effects of these physicochemical properties in the gut through exerted effects of casein pepsin hydrolysate and ovalbumin.

The Impact of Egg Nutrient Composition and Its Consumption on Cholesterol Homeostasis

The goals of this review are to summarize the recent progress in this area and to discuss some potential benefits of egg consumption, which may contribute to cholesterol homeostasis regulation through the intestinal cholesterol absorption.

An Egg-Enriched Diet Attenuates Plasma Lipids and Mediates Cholesterol Metabolism of High-Cholesterol Fed Rats

Modification of the lipoprotein profile by an egg-enriched diet was mediated by reducing de novo cholesterol synthesis and enhancing the excretion of fecal cholesterol, via upregulation of CYP7A1 and the LDL receptor, and downregulation of HMG-CoA reductase and ACAT.

Egg White Hydrolysate Can Be a Low-Allergenic Food Material to Suppress Ectopic Fat Accumulation in Rats Fed an Equicaloric Diet.

It is indicated that dietary EW and EWH reduce hepatic and muscular fat accumulation mainly by suppressing fat absorption and supplying fat to the liver and muscles and the low-allergenic EWH can be effective for the prevention of high-fat-diet-induced obesity.

New Developments in Health and Nutritional Function Promoted by Chicken Eggs

Human studies in Japan reveal that consumption of egg yolk for 4 weeks did not result in an elevation of serum cholesterol level and there was no direct relationship between frequency of egg consumption and a risk of myocardial infarction in a 10-year follow-up study of 90,000 Japanese subjects.

Heating Has No Effect on the Net Protein Utilisation from Egg Whites in Rats

Results show that EW serve as a good source of protein, irrespective of heating, and the effects of different heating conditions on the protein utilisation rate of EW are investigated.

Health Functions of Egg Protein

The consumption of egg protein may contribute to the prevention of physical frailty and metabolic syndromes and to facilitate and encourage the use of egg white protein in future, which is high in pure protein.

Dose-Dependent Increases in Liver Cholesterol but Not Plasma Cholesterol from Consumption of One to Five Whole Eggs and No Effects from Egg Whites on Liver or Plasma Cholesterol in Hamsters.

It was concluded that consumption of two to five eggs did not significantly produce any additional effects on plasma cholesterol, whereas egg white did not possess a plasma-cholesterol-lowering activity if it was consumed at amounts similar to those in a normal human diet.



Effects of dietary soybean globulins on plasma and liver lipids and on fecal excretion of neutral sterols in rats.

  • T. OkitaM. Sugano
  • Biology, Medicine
    Journal of nutritional science and vitaminology
  • 1981
The results indicated that the antihypercholesterolemic effect of soybean protein was attributable to protein per se, and not to the carbohydrate components which were associated with the protein preparation.

Studies on the mechanism of antihypercholesterolemic action of soy protein and soy protein-type amino acid mixtures in relation to the casein counterparts in rats.

Results indicate that decreased intestinal absorption of cholesterol, and increased fecal steroid excretion are primarily responsible for the antihypercholesterolemic effect of soy protein compared with casein.

Cholesterol synthesis and degradation in normal rats fed a cholesterol-free diet with excess cystine

Results indicate that hypercholesterolemia caused by feeding of a high-cystine diet may be due to the stimulation of hepatic cholesterol synthesis and bile acid content of bile’ and fecal steroids.

Egg ovomucin attenuates hypercholesterolemia in rats and inhibits cholesterol absorption in Caco-2 cells

The results suggest that the suppression of cholesterol absorption by direct interaction between cholesterol mixed micelles and OV in the jejunal epithelia is part of the mechanism underlying the hypocholesterolemic action of OV.

Effect of biotin deficiency and supplementation on lipid metabolism in rats: cholesterol and lipoproteins.

  • S. SuchyB. Wolf
  • Biology, Medicine
    The American journal of clinical nutrition
  • 1986
The results suggest that the neurologic symptoms in biotin deficiency and in the inherited multiple carboxylase deficiencies are not due to alterations in the content of cholesterol or lipoproteins.

Effect of dietary cholesterol on cholesterol and bile acid metabolism in rats.

It is concluded that dietary cholesterol increases the formation and excretion of chenodeoxycholic acid, and also that of cholic acid but to a lesser extent, and is responsible for the diminution of tissue and blood cholesterol.

Effects of different dietary cholesterol concentrations on lipoprotein plasma concentrations and on cholesterol efflux from Fu5AH cells.

The MUFA diet induced a better lipid profile than the NCEP Step I diet; however, the increase in the cholesterol content of both diets produced similar plasma lipid changes.