Mechanism for suppression of cellular biosynthesis of prostaglandins

  title={Mechanism for suppression of cellular biosynthesis of prostaglandins},
  author={Harold W. Cook and William E. M. Lands},
BIOSYNTHESIS of prostaglandins (PGs) from unsaturated fatty acid precursors involves a complex sequence of reactions that seem to proceed rapidly in response to physiological stimuli. Studies in vitro have revealed a capacity for biosynthesis greater than would be expected from measures of tissue content1,2 or daily prostaglandin (PG) production3. Biosynthesis requires release of esterified precursor from tissue lipids4,5, and control of the hydrolytic event may be a major means of controlling… CONTINUE READING


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Current opinion in chemical biology • 2000

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