Mechanism for specificity by HMG-1 in enhanceosome assembly.

  title={Mechanism for specificity by HMG-1 in enhanceosome assembly.},
  author={K B Ellwood and Y M Yen and Reid C Johnson and Michael Carey},
  journal={Molecular and cellular biology},
  volume={20 12},
Assembly of enhanceosomes requires architectural proteins to facilitate the DNA conformational changes accompanying cooperative binding of activators to a regulatory sequence. The architectural protein HMG-1 has been proposed to bind DNA in a sequence-independent manner, yet, paradoxically, it facilitates specific DNA binding reactions in vitro. To investigate the mechanism of specificity we explored the effect of HMG-1 on binding of the Epstein-Barr virus activator ZEBRA to a natural… CONTINUE READING

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