Mechanism for proton conduction of the M(2) ion channel of influenza A virus.

@article{Mould2000MechanismFP,
  title={Mechanism for proton conduction of the M(2) ion channel of influenza A virus.},
  author={Jorgen A Mould and Huan Chen Li and C S Dudlak and James D. Lear and Andrew Pekosz and Robert A. Lamb and Lawrence H. Pinto},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 12},
  pages={8592-9}
}
The M(2) integral membrane protein of influenza A virus forms a proton-selective ion channel. We investigated the mechanism for proton transport of the M(2) protein in Xenopus oocytes using a two-electrode voltage clamp and in CV-1 cells using the whole cell patch clamp technique. Membrane currents were recorded while manipulating the external solution to alter either the total or free proton concentration or the solvent itself. Membrane conductance decreased by approximately 50% when D(2)O… CONTINUE READING

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IonsNo subtypeProtons
The M(2 ) integral membrane protein of influenza A virus forms a proton - selective ion channel .
From this , we conclude that hydrogen ions do not pass through M(2 ) as hydronium ions , but instead must interact with titratable groups that line the pore of the channel .
ProtonsNo subtypeIons
From this , we conclude that hydrogen ions do not pass through M(2 ) as hydronium ions , but instead must interact with titratable groups that line the pore of the channel .
The M(2 ) integral membrane protein of influenza A virus forms a proton - selective ion channel .
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