Mechanism for increased hippocampal synaptic strength following differential experience.

@article{Foster2001MechanismFI,
  title={Mechanism for increased hippocampal synaptic strength following differential experience.},
  author={Thomas C. Foster and Theodore C Dumas},
  journal={Journal of neurophysiology},
  year={2001},
  volume={85 4},
  pages={
          1377-83
        }
}
Exposure to novel environments or behavioral training is associated with increased strength at hippocampal synapses. The present study employed quantal analysis techniques to examine the mechanism supporting changes in synaptic transmission that occur following differential behavioral experience. Measures of CA1 synaptic strength were obtained from hippocampal slices of rats exposed to novel environments or maintained in individual cages. The input/output (I/O) curve of extracellularly recorded… 
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References

SHOWING 1-10 OF 50 REFERENCES
Mechanism of altered synaptic strength due to experience: relation to long-term potentiation
Altered synaptic transmission in dentate gyrus of rats reared in complex environments: evidence from hippocampal slices maintained in vitro.
TLDR
The results suggest that experience in a relatively complex environment is associated with greater MPP synaptic transmission arising from an increased synaptic input to granule cells and the experience-dependent synaptic alterations in the dentate gyrus are transient, in contrast to experience- dependent morphological alterations described in occipital cortex.
Developmental increase in CA3-CA1 presynaptic function in the hippocampal slice.
TLDR
The results demonstrate that synaptic strength is altered over the course of development because of, at least in part, changes in presynaptic release mechanisms, and provide an explanation of differences in mechanisms for expression of long-term potentiation.
Region‐specific age effects on AMPA sensitivity: Electrophysiological evidence for loss of synaptic contacts in hippocampal field CA1
TLDR
The data do support the conclusion that there are fewer synapses per Schaffer collateral branch in old versus young CA1 pyramidal cells, and the pattern of results obtained in the present experiments supports the following conclusions.
Receptor blockade reveals a correspondence between hippocampal-dependent behavior and experience-dependent synaptic enhancement
Analysis of NMDA‐independent long‐term potentiation induced at CA3—CA1 synapses in rat hippocampus in vitro
TLDR
The results suggest that calcium entering via NMDA receptors initiates the signalling cascade that results in enhanced AMPA currents because it is adding to cytoplasmic calcium from other sources to reach a threshold for this signalling pathway.
Paired‐pulse facilitation and depression at unitary synapses in rat hippocampus: quantal fluctuation affects subsequent release.
TLDR
It is proposed that multiple release sites are formed by the axon of a CA3 pyramidal cell and a single postsynaptic CA1 or CA3 cell and it is concluded that PPD results from a decrease in quantal content, perhaps due to short‐term depletion of readily releasable vesicles.
Development of excitatory circuitry in the hippocampus.
TLDR
It is found that from neonatal to adult ages, functional synapses are created and serve to increase the degree of connectivity between CA3-CA1 cell pairs and the variability of quantal events decreases substantially as synapses mature.
An investigation of the expression mechanism of LTP of AMPA receptor-mediated synaptic transmission at hippocampal CA1 synapses using failures analysis and dendritic recordings
Long-term potentiation is associated with increases in quantal content and quantal amplitude
TLDR
Clear evidence is reported for quanta! fluctuation in a subset of cells that causes abrupt increases in either quantal content or quantal amplitude, or both, shows that two different mechanisms can underlie the maintenance of LTP.
...
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