Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1.

@article{Lu2008MechanismFC,
  title={Mechanism for coordinated RNA packaging and genome replication by rotavirus polymerase VP1.},
  author={Xiaohui Lu and Sarah M. McDonald and M A Tortorici and Yizhi Jane Tao and Rodrigo V{\'a}squez-del Carpi{\'o} and Max L Nibert and John T Patton and Stephen C Harrison},
  journal={Structure},
  year={2008},
  volume={16 11},
  pages={
          1678-88
        }
}
Rotavirus RNA-dependent RNA polymerase VP1 catalyzes RNA synthesis within a subviral particle. This activity depends on core shell protein VP2. A conserved sequence at the 3' end of plus-strand RNA templates is important for polymerase association and genome replication. We have determined the structure of VP1 at 2.9 A resolution, as apoenzyme and in complex with RNA. The cage-like enzyme is similar to reovirus lambda3, with four tunnels leading to or from a central, catalytic cavity. A… CONTINUE READING
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