Mechanism for Astral Microtubule Capture by Cortical Bud6p Priming Spindle Polarity in S. cerevisiae

@article{Hoopen2012MechanismFA,
  title={Mechanism for Astral Microtubule Capture by Cortical Bud6p Priming Spindle Polarity in S. cerevisiae},
  author={Rogier ten Hoopen and Cristina Cepeda-Garc{\'i}a and Rosario Fern{\'a}ndez-Arruti and M Angeles Juanes and Nathalie Delgehyr and Marisa Segal},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={1075-1083}
}
BACKGROUND Budding yeast is a unique model to dissect spindle orientation in a cell dividing asymmetrically. In yeast, this process begins with the capture of pole-derived astral microtubules (MTs) by the polarity determinant Bud6p at the cortex of the bud in G(1). Bud6p couples MT growth and shrinkage with spindle pole movement relative to the contact site. This activity resides in N-terminal sequences away from a domain linked to actin organization. Kip3p (kinesin-8), a MT depolymerase, may… CONTINUE READING