Mechanism by which metformin reduces glucose production in type 2 diabetes.

@article{Hundal2000MechanismBW,
  title={Mechanism by which metformin reduces glucose production in type 2 diabetes.},
  author={Ripudaman S Hundal and Martin Kr{\vs}{\vs}{\'a}k and Sylvie Dufour and Didier D. Laurent and Vincent Lebon and Visvanathan C Chandramouli and Silvio E. Inzucchi and William C. Schumann and Kitt Falk Petersen and Bernard R. Landau and Gerald I Shulman},
  journal={Diabetes},
  year={2000},
  volume={49 12},
  pages={
          2063-9
        }
}
To examine the mechanism by which metformin lowers endogenous glucose production in type 2 diabetic patients, we studied seven type 2 diabetic subjects, with fasting hyperglycemia (15.5 +/- 1.3 mmol/l), before and after 3 months of metformin treatment. Seven healthy subjects, matched for sex, age, and BMI, served as control subjects. Rates of net hepatic glycogenolysis, estimated by 13C nuclear magnetic resonance spectroscopy, were combined with estimates of contributions to glucose production… CONTINUE READING

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