Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis.

@article{Yan2006MechanismBW,
  title={Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis.},
  author={Huajun Yan and Patrick Frost and Yijiang Shi and Bao Q. Hoang and Sanjai Sharma and Myrna L Fisher and Joseph Gera and Alan K Lichtenstein},
  journal={Cancer research},
  year={2006},
  volume={66 4},
  pages={2305-13}
}
Mammalian target of rapamycin (mTOR) inhibitors curtail cap-dependent translation. However, they can also induce post-translational modifications of proteins. We assessed both effects to understand the mechanism by which mTOR inhibitors like rapamycin sensitize multiple myeloma cells to dexamethasone-induced apoptosis. Sensitization was achieved in multiple myeloma cells irrespective of their PTEN or p53 status, enhanced by activation of AKT, and associated with stimulation of both intrinsic… CONTINUE READING

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