Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.

@article{Behrens2010MechanismBW,
  title={Mechanism by which HLA-DR4 regulates sex-bias of arthritis in humanized mice.},
  author={Marshall D. Behrens and Theodore R Trejo and Harvinder S. Luthra and Marie M. Griffiths and Chella S. David and Veena Taneja},
  journal={Journal of autoimmunity},
  year={2010},
  volume={35 1},
  pages={1-9}
}
HLA class II allele DRB1*0401 is associated with predisposition to Rheumatoid Arthritis in humans as well as collagen-induced arthritis in mice. Predominantly females develop arthritis in humans and DR4 transgenic mice; however the mechanism of sex-bias is still unknown. We have investigated the molecular basis by which DR4 is associated with sex-bias of… CONTINUE READING