Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release.

@article{Chen2010MechanismbasedTD,
  title={Mechanism-based tumor-targeting drug delivery system. Validation of efficient vitamin receptor-mediated endocytosis and drug release.},
  author={Shuyi Chen and Xianrui Zhao and Jingyi Chen and Jin Chen and Larisa V. Kuznetsova and Stanislaus S Wong and Iwao Ojima},
  journal={Bioconjugate chemistry},
  year={2010},
  volume={21 5},
  pages={979-87}
}
An efficient mechanism-based tumor-targeting drug delivery system, based on tumor-specific vitamin-receptor mediated endocytosis, has been developed. The tumor-targeting drug delivery system is a conjugate of a tumor-targeting molecule (biotin: vitamin H or vitamin B-7), a mechanism-based self-immolative linker and a second-generation taxoid (SB-T-1214) as… CONTINUE READING