Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain

@article{Sisignano2014MechanismbasedTF,
  title={Mechanism-based treatment for chemotherapy-induced peripheral neuropathic pain},
  author={Marco Sisignano and Robert M. Baron and Klaus Scholich and Gerd Geisslinger},
  journal={Nature Reviews Neurology},
  year={2014},
  volume={10},
  pages={694-707}
}
Chemotherapy-induced peripheral neuropathic pain (CIPNP)—a severe adverse effect observed in up to 80% of patients during treatment with antineoplastic drugs—limits the tolerable dose of cytostatics, and can lead to discontinuation of chemotherapy. Many drugs that are approved for the treatment of other neuropathic pain states have shown little or no analgesic effect on CIPNP in large randomized, placebo-controlled clinical trials. Here, we review the known mechanisms of CIPNP induced by the… CONTINUE READING
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