Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats.

@article{Landersdorfer2009MechanismbasedMO,
  title={Mechanism-based modeling of nutritional and leptin influences on growth in normal and type 2 diabetic rats.},
  author={Cornelia B. Landersdorfer and Debra C. DuBois and Richard R. Almon and William J. Jusko},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2009},
  volume={328 2},
  pages={644-51}
}
Influences of genetic and nutritional factors on body weight, fat mass, and leptin production and effects of leptin were assessed in normal [Wistar-Kyoto (WKY)] and diabetic [Goto-Kakizaki (GK)] rats by mechanism-based modeling. The study included 60 WKY and 60 GK rats; half received high-fat diet (HF), and the others received normal rat chow (N). Body… CONTINUE READING