Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase.

  title={Mechanism-based inhibitors of CD38: a mammalian cyclic ADP-ribose synthetase.},
  author={Anthony A. Sauve and Vern L Schramm},
  volume={41 26},
The soluble domain of human CD38 catalyzes the conversion of NAD(+) to cyclic ADP-ribose and to ADP-ribose via a common covalent intermediate [Sauve, A. A., Deng, H. T., Angelletti, R. H., and Schramm, V. L. (2000) J. Am. Chem. Soc. 122, 7855-7859]. Here we establish that mechanism-based inhibitors can be produced by chemical stabilization of this intermediate. The compounds nicotinamide 2'-deoxyriboside (1), 5-methylnicotinamide 2'-deoxyriboside (2), and pyridyl 2'-deoxyriboside (3) were… CONTINUE READING
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