Corpus ID: 19935920

Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin.

@article{Chun2001MechanismbasedIO,
  title={Mechanism-based inhibition of human cytochrome P450 1A1 by rhapontigenin.},
  author={Y. Chun and S. Ryu and T. Jeong and M. Y. Kim},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2001},
  volume={29 4 Pt 1},
  pages={
          389-93
        }
}
  • Y. Chun, S. Ryu, +1 author M. Y. Kim
  • Published 2001
  • Medicine, Chemistry
  • Drug metabolism and disposition: the biological fate of chemicals
Recently we reported that resveratrol (trans-3,4',5-trihydroxystilbene) showed selective inhibition of recombinant human cytochrome P450 (P450) 1A1 in a concentration-dependent manner. The inhibition of recombinant human P450 1A1, 1A2, or 1B1 by various hydroxystilbene compounds having a similar structure to resveratrol was investigated using bacterial membranes from a human P450/NADPH-P450 reductase bicistronic expression system to find new candidates for cancer chemopreventive agents. Of… Expand
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The results suggest that resveratrol is a selective human P450 1A1 inhibitor, and may be considered for use as a strong cancer chemopreventive agent in humans. Expand
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