Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

  title={Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.},
  author={Shu-Feng Zhou and Sui Yung Chan and Boon Cher Goh and Eli Chan and Wei Duan and Min Huang and Ping Liao},
  journal={Clinical pharmacokinetics},
  volume={44 3},
Consistent with its highest abundance in humans, cytochrome P450 (CYP) 3A is responsible for the metabolism of about 60% of currently known drugs. However, this unusual low substrate specificity also makes CYP3A4 susceptible to reversible or irreversible inhibition by a variety of drugs. Mechanism-based inhibition of CYP3A4 is characterised by nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)-, time- and concentration-dependent enzyme inactivation, occurring when some drugs are… CONTINUE READING


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