Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications.

@article{Hollenberg2008MechanismbasedIO,
  title={Mechanism-based inactivation of human cytochromes p450s: experimental characterization, reactive intermediates, and clinical implications.},
  author={Paul F. Hollenberg and Ute M. Kent and Namandj{\'e} N Bumpus},
  journal={Chemical research in toxicology},
  year={2008},
  volume={21 1},
  pages={
          189-205
        }
}
The P450 type cytochromes are responsible for the metabolism of a wide variety of xenobiotics and endogenous compounds. Although P450-catalyzed reactions are generally thought to lead to detoxication of xenobiotics, the reactions can also produce reactive intermediates that can react with cellular macromolecules leading to toxicity or that can react with the P450s that form them leading to irreversible (i.e., mechanism-based) inactivation. This perspective describes the fundamentals of… CONTINUE READING
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