Mechanism-based candidate inhibitors of uridine diphosphate galactopyranose mutase (UGM).

@article{MahdaviAmiri2016MechanismbasedCI,
  title={Mechanism-based candidate inhibitors of uridine diphosphate galactopyranose mutase (UGM).},
  author={Yasaman Mahdavi-Amiri and Sankar Mohan and Silvia Borrelli and Kathryn Slowski and David A. R. Sanders and Brian Mario Pinto},
  journal={Carbohydrate research},
  year={2016},
  volume={419},
  pages={1-7}
}
Uridine diphosphate-galactopyranose mutase (UGM), an enzyme found in many eukaryotic and prokaryotic human pathogens, catalyzes the interconversion of UDP-galactopyranose (UDP-Galp) and UDP-galactofuranose (UDP-Galf), the latter being used as the biosynthetic precursor of the galactofuranose polymer portion of the mycobacterium cell wall. We report here the… CONTINUE READING