Mechanism-based cancer therapy: resistance to therapy, therapy for resistance

@article{Ramos2015MechanismbasedCT,
  title={Mechanism-based cancer therapy: resistance to therapy, therapy for resistance},
  author={Patricio Ramos and Mohamed Bentires-Alj},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={3617-3626}
}
The introduction of targeted therapy promised personalized and efficacious cancer treatments. However, although some targeted therapies have undoubtedly improved prognosis and outcome for specific cancer patients, the recurrent problem of therapeutic resistance subdues present revolutionary claims in this field. The plasticity of tumor cells leads to the development of drug resistance by distinct mechanisms: (1) mutations in the target, (2) reactivation of the targeted pathway, (3… CONTINUE READING
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