Mechanism-based cancer risk assessment of butylated hydroxyanisole.

  title={Mechanism-based cancer risk assessment of butylated hydroxyanisole.},
  author={John Whysner},
  journal={Toxicology and industrial health},
  volume={9 1-2},
  • John Whysner
  • Published 1993 in Toxicology and industrial health
The evidence for BHA-induced carcinogenicity is restricted to the rodent non-glandular stomach, which is not found in humans. Although an argument can be made that an effect in this target organ could be indicative of potential carcinogenicity in other tissues, particularly the esophagus, studies have not revealed such a correlation. BHA-induced proliferative effects, which appear to be critical for the tumorigenic response, show a NOEL at a dose below that yielding benign tumors. The NOEL of… CONTINUE READING