Mechanism-based biomarker gene sets for glutathione depletion-related hepatotoxicity in rats.

  title={Mechanism-based biomarker gene sets for glutathione depletion-related hepatotoxicity in rats.},
  author={Weihua Gao and Yumiko Mizukawa and Noriyuki Nakatsu and Yosuke Minowa and Hiroshi Yamada and Yasuo Ohno and Tetsuro Urushidani},
  journal={Toxicology and applied pharmacology},
  volume={247 3},
Chemical-induced glutathione depletion is thought to be caused by two types of toxicological mechanisms: PHO-type glutathione depletion [glutathione conjugated with chemicals such as phorone (PHO) or diethyl maleate (DEM)], and BSO-type glutathione depletion [i.e., glutathione synthesis inhibited by chemicals such as l-buthionine-sulfoximine (BSO)]. In order to identify mechanism-based biomarker gene sets for glutathione depletion in rat liver, male SD rats were treated with various chemicals… CONTINUE READING


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