Mechanism-based approaches to treating fragile X.

@article{Dlen2010MechanismbasedAT,
  title={Mechanism-based approaches to treating fragile X.},
  author={G{\"u}l D{\"o}len and Randall L. Carpenter and Timothy Ocain and Mark F. Bear},
  journal={Pharmacology & therapeutics},
  year={2010},
  volume={127 1},
  pages={78-93}
}
Fragile X is the leading inherited cause of mental retardation and autism. Recent advances in our mechanistic understanding of the disease have led to the identification of the metabotropic glutamate receptor (mGluR) as a therapeutic target for the disease. These studies have revealed that core defects in multiple animal models can be corrected by down regulation of mGluR5 signaling. Although it remains to be seen if mGluR5 antagonists or related approaches will succeed in humans with fragile X… CONTINUE READING