Mechanism and stability of hyperproduction of the extended-spectrum beta-lactamase SHV-5 in Klebsiella pneumoniae.

@article{Xiang1997MechanismAS,
  title={Mechanism and stability of hyperproduction of the extended-spectrum beta-lactamase SHV-5 in Klebsiella pneumoniae.},
  author={Xin-ying Xiang and Kevin P Shannon and Gary L. French},
  journal={The Journal of antimicrobial chemotherapy},
  year={1997},
  volume={40 4},
  pages={525-32}
}
Some isolates of SHV-5 beta-lactamase-producing Klebsiella pneumoniae K2 from a single-strain outbreak of cross-infection produced approximately five-fold more beta-lactamase than others. We investigated three possible genetic mechanisms of this hyperproduction: the presence of a more powerful promoter, an increase in plasmid copy number or an amplification of the gene on a plasmid. No differences between low and high beta-lactamase producers were detected in the promoter region of the SHV-5… CONTINUE READING

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