Mechanism and site of small intestinal uptake of vitamin D3 in pharmacological concentrations.

@article{Hollander1976MechanismAS,
  title={Mechanism and site of small intestinal uptake of vitamin D3 in pharmacological concentrations.},
  author={Daniel den Hollander and T C Truscott},
  journal={The American journal of clinical nutrition},
  year={1976},
  volume={29 9},
  pages={970-5}
}
The site and mechanism of initial uptake of 1,2-3H vitamin D3 pharmacological concentrations was investigated using everted rat small bowel sacs incubated in a micellar medium. The mean +/- SE uptake rates of the vitamin at 300 muM incubation solution concentration by proximal, medial, and distal small bowel segments were 6.7 +/- 0.26, 7.8 +/- 0.54, and 3.3 +/- 0.20 nmole/min/100 mg tissue, respectively. Incubation with the addition of 10(-3) M 2,4-dinitrophenol, or 10(-3) M KCN, or under… CONTINUE READING

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