Mechanism and regulation of human non-homologous DNA end-joining

@article{Lieber2003MechanismAR,
  title={Mechanism and regulation of human non-homologous DNA end-joining},
  author={Michael R. Lieber and Yunmei Ma and Ulrich Pannicke and Klaus W. Schwarz},
  journal={Nature Reviews Molecular Cell Biology},
  year={2003},
  volume={4},
  pages={712-720}
}
Non-homologous DNA end-joining (NHEJ) — the main pathway for repairing double-stranded DNA breaks — functions throughout the cell cycle to repair such lesions. Defects in NHEJ result in marked sensitivity to ionizing radiation and ablation of lymphocytes, which rely on NHEJ to complete the rearrangement of antigen-receptor genes. NHEJ is typically imprecise, a characteristic that is useful for immune diversification in lymphocytes, but which might also contribute to some of the genetic changes… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 450 CITATIONS, ESTIMATED Infinity% COVERAGE

450 Citations

0102030'06'09'12'15'18
Citations per Year
Semantic Scholar estimates that this publication has 450 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
SHOWING 1-10 OF 114 REFERENCES

Autophosphorylation of the DNAdependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks

  • Chan, W D.
  • Genes Dev. 16,
  • 2002

Similar Papers

Loading similar papers…