Mechanism and impact of allosteric AMPA receptor modulation by the AmpakineTM CX546

@article{Nagarajan2001MechanismAI,
  title={Mechanism and impact of allosteric AMPA receptor modulation by the AmpakineTM CX546},
  author={Naveen Nagarajan and Christoph Quast and Andrew R. Boxall and Mohammed Shahid and Christian Rosenmund},
  journal={Neuropharmacology},
  year={2001},
  volume={41},
  pages={650-663}
}

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  • M. Black
  • Biology, Psychology
    Psychopharmacology
  • 2004
Preclinical work on positive AMPA modulators is reviewed to suggest that positive modulation of AMPA may offer numerous therapeutic avenues for central nervous system drug discovery.

Investigation of the Functional Effects of Two Novel Ampakines in the CNS

The semi-quantitative [C]-2-deoxyglucose model was reproducible and accurate and thus could be further used to investigate the effects of the novel Ampakines, Org 26576 and Org 24448, on cerebral function.

Mechanism of glutamate receptor desensitization

Using the GluR2 AMPA-sensitive glutamate receptor, it is shown that the ligand-binding cores form dimers and that stabilization of the intradimer interface by either mutations or allosteric modulators reduces desensitization.
...

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