Mechanism and evolution of protein dimerization.

@article{Xu1998MechanismAE,
  title={Mechanism and evolution of protein dimerization.},
  author={Dong Xu and C. J. Tsai and Ruth Nussinov},
  journal={Protein science : a publication of the Protein Society},
  year={1998},
  volume={7 3},
  pages={
          533-44
        }
}
We have investigated the mechanism and the evolutionary pathway of protein dimerization through analysis of experimental structures of dimers. We propose that the evolution of dimers may have multiple pathways, including (1) formation of a functional dimer directly without going through an ancestor monomer, (2) formation of a stable monomer as an intermediate followed by mutations of its surface residues, and (3), a domain swapping mechanism, replacing one segment in a monomer by an equivalent… CONTINUE READING
BETA
Tweets
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
SHOWING 1-10 OF 40 CITATIONS

Similar Papers

Loading similar papers…