Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening.

@article{Yeh2011MechanismAC,
  title={Mechanism and consequence of chitosan-mediated reversible epithelial tight junction opening.},
  author={Tzyy-Harn Yeh and L Hsu and Michael T. Tseng and Pei-Ling Lee and Kiran Sonjae and Yi-Cheng Ho and H. -I. Sung},
  journal={Biomaterials},
  year={2011},
  volume={32 26},
  pages={6164-73}
}
In order to increase the absorption of hydrophilic macromolecules in the small intestine, permeation enhancers such as chitosan (CS) and its derivatives have been evaluated. The aim of the current work was to investigate, on molecular levels, the effect of CS on tight junction (TJ) integrity in Caco-2 cells. The observed changes in transepithelial-electrical-resistance measurements and the staining patterns of the monolayer Caco-2 cells demonstrate that CS can transiently and reversibly open… CONTINUE READING