Mechanism and Regulation of Acetylated Histone Binding by the Tandem PHD Finger of DPF3b

@inproceedings{Zeng2010MechanismAR,
  title={Mechanism and Regulation of Acetylated Histone Binding by the Tandem PHD Finger of DPF3b},
  author={Lei Zeng and Qiang Zhang and Side Li and Alexander N. Plotnikov and Martin J. Walsh and Ming-Ming Zhou},
  booktitle={Nature},
  year={2010}
}
Histone lysine acetylation and methylation have an important role during gene transcription in a chromatin context. Knowledge concerning the types of protein modules that can interact with acetyl-lysine has so far been limited to bromodomains. Recently, a tandem plant homeodomain (PHD) finger (PHD1–PHD2, or PHD12) of human DPF3b, which functions in association with the BAF chromatin remodelling complex to initiate gene transcription during heart and muscle development, was reported to bind… CONTINUE READING

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