Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling—A New Classification of Biomarkers

@article{Danhof2005MechanismBasedPM,
  title={Mechanism-Based Pharmacokinetic–Pharmacodynamic Modeling—A New Classification of Biomarkers},
  author={Meindert Danhof and Gunnar Alv{\'a}n and Svein G. Dahl and Jochen Kuhlmann and Gilles Paintaud},
  journal={Pharmaceutical Research},
  year={2005},
  volume={22},
  pages={1432-1437}
}
In recent years, pharmacokinetic/pharmacodynamic (PK/PD) modeling has developed from an empirical descriptive discipline into a mechanistic science that can be applied at all stages of drug development. Mechanism-based PK/PD models differ from empirical descriptive models in that they contain specific expressions to characterize processes on the causal path between drug administration and effect. Mechanism-based PK/PD models have much improved properties for extrapolation and prediction. As… CONTINUE READING