Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model.

@article{Lin2018MechanismBasedPM,
  title={Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling of Aerosolized Colistin in a Mouse Lung Infection Model.},
  author={Yu-Wei Lin and Qi Tony Zhou and Mei-Ling Han and Nikolas J Onufrak and Ke Chen and Jiping Wang and Alan Forrest and Hak-kim Chan and Jichang Li},
  journal={Antimicrobial agents and chemotherapy},
  year={2018},
  volume={62 3}
}
Optimized dosage regimens of aerosolized colistin (as colistin methanesulfonate [CMS]) are urgently required to maximize bacterial killing against multidrug-resistant Gram-negative bacteria while minimizing toxicity. This study aimed to develop a mechanism-based pharmacokinetic (PK)/pharmacodynamic (PD) model (MBM) for aerosolized colistin based upon PK/PD… CONTINUE READING