Mechanism-Based Inactivation of Human Cytochrome P 450 3 A 4 by Two Piperazine-Containing Compounds s

Abstract

Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of more than half of pharmaceutic drugs, and inactivation of CYP3A4 can lead to adverse drug-drug interactions. The substituted imidazole compounds 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl) methyl]-1-piperazinyl]pyrimidine (SCH 66712) and 1-[(2-ethyl-4-methyl1H-imidazol-5-yl)methyl]-4-[4… (More)

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