Mechanism‐based models for topotecan‐induced neutropenia

@article{Lger2004MechanismbasedMF,
  title={Mechanism‐based models for topotecan‐induced neutropenia},
  author={Fr{\'e}d{\'e}ric L{\'e}ger and Walter J. Loos and Roland Bugat and Ron H. J. Mathijssen and Marine Goffinet and Jaap Verweij and Alex Sparreboom and Etienne Chatelut},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2004},
  volume={76}
}
A semiphysiologic pharmacokinetic‐pharmacodynamic model was applied to describe topotecan‐induced neutropenia, to quantify interindividual and intraindividual pharmacodynamic variability, and to study the effect of covariates on the model. 
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