Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering.

@article{Nerurkar2007MechanicsOO,
  title={Mechanics of oriented electrospun nanofibrous scaffolds for annulus fibrosus tissue engineering.},
  author={Nandan L. Nerurkar and Dawn M. Elliott and Robert L Mauck},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2007},
  volume={25 8},
  pages={1018-28}
}
Engineering a functional replacement for the annulus fibrosus (AF) of the intervertebral disc is contingent upon recapitulation of AF structure, composition, and mechanical properties. In this study, we propose a new paradigm for AF tissue engineering that focuses on the reconstitution of anatomic fiber architecture and uses constitutive modeling to evaluate construct function. A modified electrospinning technique was utilized to generate aligned nanofibrous polymer scaffolds for engineering… CONTINUE READING