Mechanics of dynamin-mediated membrane fission.

  title={Mechanics of dynamin-mediated membrane fission.},
  author={Sandrine Morlot and Aur{\'e}lien Roux},
  journal={Annual review of biophysics},
In eukaryotic cells, membrane compartments are split into two by membrane fission. This ensures discontinuity of membrane containers and thus proper compartmentalization. The first proteic machinery implicated in catalyzing membrane fission was dynamin. Dynamin forms helical collars at the neck of endocytic buds. This structural feature suggested that the helix of dynamin could constrict in order to promote fission of the enclosed membrane. However, verifying this hypothesis revealed itself to… CONTINUE READING

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