Mechanics of Motor Proteins and the Cytoskeleton

  title={Mechanics of Motor Proteins and the Cytoskeleton},
  author={Jonathon Howard and Rl Clark},
Preface - Introduction - PART I: PHYSICAL PRINCIPLES - Mechanical Forces - Mass, Stiffness, and Damping of Proteins - Thermal Forces and Diffusion - Chemical Forces - Polymer Mechanics - PART II: CYTOSKELETON - Structures of Cytoskeletal Filaments - Mechanics of the Cytoskeleton - Polymerization of Cytoskeletal Filaments - Force Generation by Cytoskeletal Filaments - Active Polymerization - PART III: MOTOR PROTEINS - Structures of Motor Proteins - Speeds of Motors - ATP Hydrolysis - Steps and… 

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Intermediate FiIammts'l'46 Bacterinl EIagellum 146 DNAandTitin 1'47 Summary: Material ProPertiesof CvtoskeletalProteins 147
    Re-cently, we used such a motility assay to study the dynam-ics of actin bundles induced by the cooperative action of myosin II motors
      inproceedings{Howard2001MechanicsOM, title={Mechanics of Motor Proteins and the Cytoskeleton}, author={J
      • Howard and R. Clark},
      • 2001
      Motor proteins are molecular machines that convert the chemical energy derived from the hydrolysis of ATP into mechanical work used to power cellular motility
      • In addition to specialized motile cells... J. Howard, Mechanics of Motor Proteins and the Cytoskeleton (Ed. Sinauer Associates,
      • 2001
      All rights reserved. This b.ook may not be published in whole or in part without permission from th
        often studied using in vitro motility assays in which the la-ments glide over a dense bed of immobilized motors and their motion is tracked by uorescent microscopy
        • 2001
        Materials Rigidityof Keratin-Containing 1t1. Rigidity of Filaments in Vitro 143 AetinFilammtsL43 Mitotubules 144 CoiledCoils1