Mechanics of Channel Gating of the Nicotinic Acetylcholine Receptor

Abstract

The nicotinic acetylcholine receptor (nAChR) is a key molecule involved in the propagation of signals in the central nervous system and peripheral synapses. Although numerous computational and experimental studies have been performed on this receptor, the structural dynamics of the receptor underlying the gating mechanism is still unclear. To address the… (More)
DOI: 10.1371/journal.pcbi.0040019

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