Mechanics and Dynamics of X-Chromosome Pairing at X Inactivation


At the onset of X-chromosome inactivation, the vital process whereby female mammalian cells equalize X products with respect to males, the X chromosomes are colocalized along their Xic (X-inactivation center) regions. The mechanism inducing recognition and pairing of the X's remains, though, elusive. Starting from recent discoveries on the molecular factors… (More)
DOI: 10.1371/journal.pcbi.1000244


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