Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling.

@article{Ito2005MechanicsNA,
  title={Mechanics, nonlinearity, and failure strength of lung tissue in a mouse model of emphysema: possible role of collagen remodeling.},
  author={Satoru Ito and Edward P. Ingenito and Kelly K Brewer and Lauren Deems Black and Harikrishnan Parameswaran and Kenneth R. Lutchen and B{\'e}la Suki},
  journal={Journal of applied physiology},
  year={2005},
  volume={98 2},
  pages={503-11}
}
Enlargement of the respiratory air spaces is associated with the breakdown and reorganization of the connective tissue fiber network during the development of pulmonary emphysema. In this study, a mouse (C57BL/6) model of emphysema was developed by direct instillation of 1.2 IU of porcine pancreatic elastase (PPE) and compared with control mice treated with saline. The PPE treatment caused 95% alveolar enlargement (P = 0.001) associated with a 29% lower elastance along the quasi-static pressure… CONTINUE READING

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