Mechanically unloading the left ventricle before coronary reperfusion reduces left ventricular wall stress and myocardial infarct size.

@article{Kapur2013MechanicallyUT,
  title={Mechanically unloading the left ventricle before coronary reperfusion reduces left ventricular wall stress and myocardial infarct size.},
  author={Navin K Kapur and Vikram Paruchuri and Jose Angel Urbano-Morales and Emily E. Mackey and Gerard H. Daly and Xiaoying Qiao and Natesa Pandian and George Perides and Richard H Karas},
  journal={Circulation},
  year={2013},
  volume={128 4},
  pages={328-36}
}
BACKGROUND Ischemia/reperfusion injury worsens infarct size, a major determinant of morbidity and mortality after acute myocardial infarction (MI). We tested the hypothesis that reducing left ventricular wall stress with a percutaneous left atrial-to-femoral artery centrifugal bypass system while delaying coronary reperfusion limits myocardial injury in a model of acute MI. METHODS AND RESULTS MI was induced by balloon occlusion of the left anterior descending artery in adult male swine. In… CONTINUE READING
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