Mechanically induced trauma suffered by cancer cells in passing through pores in polycarbonate membranes.

@article{Gbor1985MechanicallyIT,
  title={Mechanically induced trauma suffered by cancer cells in passing through pores in polycarbonate membranes.},
  author={Horvath G{\'a}bor and Leonard Weiss},
  journal={Invasion & metastasis},
  year={1985},
  volume={5 2},
  pages={71-83}
}
As mechanically induced trauma to cancer cells passing through the micro-circulation may well modify their metastatic behavior, we have categorized the damage done to cultured L1210 and Ehrlich ascites tumor cells passing through 5-12 micron pores in polycarbonate membranes, as a simple, albeit limited in vitro mechanical model. It was shown that in passing through membrane pores, impaired cell reproductive integrity and 3H-thymidine incorporation were the first detected signs of trauma… CONTINUE READING