Mechanically activated integrin switch controls alpha5beta1 function.

  title={Mechanically activated integrin switch controls alpha5beta1 function.},
  author={Julie C. Friedland and Mark H. Lee and David Boettiger},
  volume={323 5914},
The cytoskeleton, integrin-mediated adhesion, and substrate stiffness control a common set of cell functions required for development and homeostasis that are often deranged in cancer. The connection between these mechanical elements and chemical signaling processes is not known. Here, we show that alpha(5)beta(1) integrin switches between relaxed and tensioned states in response to myosin II-generated cytoskeletal force. Force combines with extracellular matrix stiffness to generate tension… CONTINUE READING
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