Mechanically Activated Integrin Switch Controls α5β1 Function

@article{Friedland2009MechanicallyAI,
  title={Mechanically Activated Integrin Switch Controls $\alpha$5$\beta$1 Function},
  author={Julie C. Friedland and Mark H. Lee and D. Boettiger},
  journal={Science},
  year={2009},
  volume={323},
  pages={642 - 644}
}
The cytoskeleton, integrin-mediated adhesion, and substrate stiffness control a common set of cell functions required for development and homeostasis that are often deranged in cancer. The connection between these mechanical elements and chemical signaling processes is not known. Here, we show that α5β1 integrin switches between relaxed and tensioned states in response to myosin II–generated cytoskeletal force. Force combines with extracellular matrix stiffness to generate tension that triggers… Expand
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