Mechanical ventilation with positive end-expiratory pressure decreases release of alpha-atrial natriuretic peptide.


The influence of PEEP during controlled mechanical ventilation (CMV) on plasma levels of alpha-atrial natriuretic peptide (alpha-ANP) was examined in seven patients suffering from acute respiratory failure. The majority of patients were volume-expanded. Samples were drawn from the superior vena cava, right atrium, pulmonary artery, and radial artery. All… (More)