Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin.

@article{Altemeier2004MechanicalVW,
  title={Mechanical ventilation with moderate tidal volumes synergistically increases lung cytokine response to systemic endotoxin.},
  author={William A Altemeier and Gustavo Matute-Bello and Charles W Frevert and Yasunobu Kawata and Osamu Kajikawa and Thomas R. Martin and Robb W. Glenny},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2004},
  volume={287 3},
  pages={L533-42}
}
Previous animal studies have identified a role for activation of innate immunity in the pathogenesis of ventilator-associated lung injury. These studies have used large tidal volume ventilation to study the effect of alveolar overdistension on induction of inflammatory pathways. We hypothesized an alternative mechanism for the pathogenesis of lung injury in… CONTINUE READING