Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury.

@article{Wolthuis2008MechanicalVW,
  title={Mechanical ventilation with lower tidal volumes and positive end-expiratory pressure prevents pulmonary inflammation in patients without preexisting lung injury.},
  author={Esther K. Wolthuis and Goda C W Choi and Mark C Dessing and Paul Bresser and Ren{\'e} Lutter and Misa Dzoljic and Tom van der Poll and Margreeth B. Vroom and Markus Hollmann and Marcus J. Schultz},
  journal={Anesthesiology},
  year={2008},
  volume={108 1},
  pages={46-54}
}
BACKGROUND Mechanical ventilation with high tidal volumes aggravates lung injury in patients with acute lung injury or acute respiratory distress syndrome. The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury. METHODS Patients scheduled to undergo an elective surgical procedure (lasting > or = 5 h) were randomly assigned to mechanical ventilation with either higher tidal volumes of 12 ml/kg… CONTINUE READING